diff --git a/CMakeLists.txt b/CMakeLists.txt
index 13b1ccd1..ac7879c0 100644
--- a/CMakeLists.txt
+++ b/CMakeLists.txt
@@ -284,6 +284,10 @@ if(${PROJECT_NAME}_PYTHON_BINDINGS)
   if(CMAKE_BUILD_TYPE MATCHES "^[Dd]eb" OR ${PROJECT_NAME}_STATIC)
     message(FATAL_ERROR "** Python Bindings are disabled in debug or static builds.")
   endif()
+  if(CMAKE_UNITY_BUILD)
+    message(FATAL_ERROR "** Python Bindings are disabled in Unity builds. "
+                        "Try again with CMAKE_UNITY_BUILD=OFF")
+  endif()
 endif()
 if(${PROJECT_NAME}_PYTHON_BINDINGS)
   add_subdirectory(python)